Our mission
Excellent basic research relies on excellent tools. Our mission is to enable basic research with chemical tools. MedChemCORe is a team of highly experienced scientists in the area of Organic and Medicinal Chemistry, Structural Biology, Biochemistry and Cheminformatics. We will provide you with tools for your research project on collaboration basis.
Access to chemical probes
and pharmacological tools
- Design and synthesis of fluorescent ligands and substrates
- Design and synthesis of PROTACs
- Design and synthesis of photo-affinity probes
- Synthesis of substrates for isotope labelling (non-radioactive, e.g. 13C, 2D)
- Synthesis of published tools
- Upscale for in vivo studies
MedChem consulting
and Virtual Screening
- Design of robust assay systems
- HTS hit list evaluation
- Hit validation (biophysical assays)
- SAR-by-catalogue
- Ligand-based Virtual Sreening
- Structure-based Virtual Screening
In vitro physicochemical
and pharmacokinetic properties
- Solubility
- Permeability studies (cellular permeability, GI, BBB)
- Stability (buffer, acidic/basic/oxidative/reductive conditions, plasma, liver microsomes)
Assay development
- HTRF-based assays (displacement, functional)
- Enzyme activity assays (fluorescent, HPLC/MS)
- Generation of stable cell lines
- BRET assays
- Reporter gene assays
- Multiplex toxicity screening
Structural Biology
- Recombinant protein expression
- X-ray crystallography
- Fragment screening
Compound libraries
- Approved drugs
- Kinase-priveledged compounds
- Drug-derived fragments
- Fatty acid mimetics
Our team
The MedChemCore team is located in the Institute for Pharmaceutical Chemistry of the Goethe University. The expertise of the team members covers the whole spectrum of assay development, hit identification, validation, and optimization.
Eugen Proschak
Eugen Proschak is currently Professor for Drug Design at the Goethe University and heads the MedChemCore. His main expertise is in hit-to-lead optimization for various target classes.
Stefan Knapp
Stefan Knapp is Professor for Medicinal Chemistry at the Goethe University. He is a highly experienced structural biologist, who contributed to the development of numerous chemical probes for kinases and epigenetic targets
Dieter Steinhilber
Dieter Steinhilber is Director of the Institute of Pharmaceutical Chemistry at the Goethe University. His expertise is the development of enzymatic and cellular assays.
Victor Hernandez-Olmos
Victor Hernandez Olmos works as a Senior Scientist for the Fraunhofer ITMP. Since 2011 he has been working as a medicinal chemist in a variety of projects. His expertise includes reaction optimization, multi-step organic synthesis, asymmetric catalysis, SAR determination, hit-to-lead optimization and combinatorial chemistry approaches.
Susanne Müller-Knapp
Susanne Müller-Knapp is Chief Operating Officer at the SGC Frankfurt. She is leading the cellular assay group specialized in phaenotypical Multiplex assays
Anna Proschak
Anna Proschak is a Senior Scientist at the Institute of Pharmaceutical Chemistry at the Goethe University. Her expertise is analytics of small molecules. She heads the in vitro PK unit at MedChemCore.
Pascal Heitel
Pascal Heitel is a junior group leader at the Goethe University. He is a medicinal chemist with expert knowledge in organic synthesis, lead optimization, PROTACs, and cellular assay systems.
Kontakt
Phone: +49 69 798 29301
Email: proschak@pharmchem.uni-frankfurt.de
Address: Max-von-Laue Str. 9, D-60438 Frankfurt a.M., Germany
Urheberrecht ©
Alle Rechte vorbehalten.
Wir benötigen Ihre Zustimmung zum Laden der Übersetzungen
Wir nutzen einen Drittanbieter-Service, um den Inhalt der Website zu übersetzen, der möglicherweise Daten über Ihre Aktivitäten sammelt. Bitte prüfen Sie die Details und akzeptieren Sie den Dienst, um die Übersetzungen zu sehen.